Scarcity Assignment Example | Topics and Well Written Essays - 250 words

Scarcity - Assignment Example A need is something that is tremendously essential for a human being to survive. It is that thing that people cannot live without; they must have it in order to stay alive. In addition, it is that one thing that people cannot function without that one thing that people must have. If a requirement is not met, it would probably result to the beginning of a disease (Bomstein and Susan 135). Also, when the need is not met, it leads to a person’s inability to function effectively. The lack of needs also makes it hard for people to purpose professionally in a society. Therefore, when the need is not met it can likely lead to death. Normally, needs remain steady all the way through the lifetime of a person. Conversely, wants are something that an individual wishes to have in life. It can be that thing that a person longs for either right away or in prospect. They are not essential for a person’s survival people can live without wants. Wants normally vary from one individual to another. Every individual has her or his list of wants, all with unreliable level of significance. In addition, wants can vary over a point in time (Bomstein and Susan189). Some of the examples of needs are; food, the air, shelter, water and clothing. On the other hand, wants are a nice car, travelling abroad, ice cream, designer t-shirt, nice shoes. The idea of my choice is based on the necessity and the most desired things by majority of the

Using Batch And Continuous Cultures Biology Essay

Using Batch And Continuous Cultures Biology Essay Microbial growth causes an increase in a microorganisms size and population number and can be studied using batch and continuous culture mediums (Lansing M. Prescott et al. 1990, 1993, p. 112) Batch cultures: Nutrient consumption and build up of toxic by-products slow down and stop the growth of bacteria. One method to avoid this is to use batch culture system. This involves culturing bacteria in liquid medium within a closed system where no fresh medium is added during the incubation period and hence the nutrient concentration declines and waste products accumulate during the growth of bacteria (Slonczewski Foster 2009, p. 137). The microorganisms reproduce by binary fission and their growth can be expressed as the logarithm of cell number and can be plotted against incubation time. This result in a curve that has 4 distinct phases as shown in Figure 1: (Lansing M. Prescott et al. 1990, 1993, p. 113) Figure 1: Curve showing phases of growth for batch cultures (taken from Tortora et al. 1992) Lag Phase- when microorganisms are introduced into fresh culture medium no increase in cell number or mass occurs. This marks the beginning of the Lag Phase which is necessary as the cells may be old and depleted of ATP, certain essential cofactors and ribosome, the medium may be different from the one that the microorganism was growing in previously, or the microorganism may have suffered injuries and may need time to recover (Lansing M. Prescott et al. 1990, 1993, p. 113). Length of the Lag Phase varies depending on factors such as age of culture, temperature changes and differences between old and new media. When cells are transferred from a complex medium to a fresh complex medium lag phase is very short, whereas when cells are transferred from complex medium into a minimally defined medium, lag phase is protracted (Slonczewski Foster 2009, p. 137). Exponential Phase- during this phase the rate of growth of microorganisms is constant and they divide and become double in number at regular intervals and at the maximal rate possible given their genetic potential, nature of the medium and the conditions of growth (Lansing M. Prescott et al. 1990, 1993, p. 113).As batch cultures are not synchronous every cell has an equal generation time and each cell divides at a different moment, as hence the cell number rises smoothly. When the medium is abruptly changed nutritional downshifts or nutritional upshifts cause cells experiencing balanced exponential growth to be thrown into metabolic chaos that is unbalanced growth (Slonczewski Foster 2009, p. 138). Exponential phase cultures are used in biochemical and physiological studies as the population is most uniform in terms of chemical and physiological characteristics during this phase (Lansing M. Prescott et al. 1990, 1993, p. 113). Stationary Phase- during this phase the growth curve becomes horizontal as growth of the population ceases. Bacteria enter this phase at a population level of around cells per ml. The total number of viable organisms remains constant due to a balance between cell division and cell death or because the population ceases to divide but still remains metabolically active. Microbial populations enter the stationary phase due to reasons such as nutrient limitations, oxygen availability and accumulation of toxic waste products (Lansing M. Prescott et al. 1990, 1993, p. 114). Death Phase- characteristic feature of this phase is decline in the number of viable cells due to nutrient deprivation and buildup of toxic wastes. The death of a microbial population is logarithmic. The extended survival of particularly resistant cells may reduce the death rate (Lansing M. Prescott et al. 1990, 1993, p. 114). In this phase the number of cells that die during a given time period is proportional to the number of cells that existed at the beginning of the time period (Slonczewski Foster 2009, p. 138). Advantages of using batch cultures: They allow versatility and can be used for many different reactions (Nielsen Villadsen 1994, p. 344). They are safe and do not pose a threat of strain mutation (Nielsen Villadsen 1994, p. 344). They ensure complete conversion of substrate (Nielsen Villadsen 1994, p. 344). The changing conditions during the use of batch cultures affect the physiology and growth of bacteria and hence highlight the ability of bacteria to adapt to its environment (Slonczewski Foster 2009, p. 137). Disadvantages of using batch cultures: Use of batch cultures requires highly skilled labor thus increasing labor costs (Nielsen Villadsen 1994, p. 344). Use of batch cultures is time consuming (Nielsen Villadsen 1994, p. 344). According to Xuezhen Kang (2000) changing concentrations of products and reactants, varying pH and oxidation-reduction potential makes interpretation of results difficult. According to Xuezhen Kang (2000) complicated mix of growing, dying and dead cells also makes interpretation difficult. Continuous cultures: In a continuous culture system the microorganisms are grown in an open system where constant environmental conditions are maintained through continuous provisions for new nutrients and removal of waste. This allows the microbial population to remain in exponential growth phase and at a constant biomass concentration for an extended period of time (Lansing M. Prescott et al. 1990, 1993, p. 120). 2 main types of continuous culture systems: Chemostat- this system ensures that sterile medium containing essential nutrients in limiting quantities is fed into the culture vessel at the same rate as the medium containing the microorganism is removed (Lansing M. Prescott et al. 1990, 1993, p. 120). The growth rate of microorganisms is determined by the rate at which new medium is fed into the growth chamber. The final cell density depends on the concentration of the limiting nutrient (Lansing M. Prescott et al. 1990, 1993, p. 120). Dilution rate D is used to express the rate of nutrient exchange and is defined as the rate at which medium flows through the culture vessel relative to the vessel volume. f represents flow rate and V represents volume of the vessel (Lansing M. Prescott et al. 1990, 1993, p. 120). D=f/V f (ml/hr) and V(ml)(Lansing M. Prescott et al.1990, 1993, p. 120) Microbial population levels and generation time depend on the dilution rate. As the dilution rate increases generation time shortens and growth rate rises. Under these conditions the limiting nutrient will be almost completely depleted and it begins to rise at higher dilution rates as there are fewer microorganisms present to use it. At low dilution rate a rise in both cell density and growth rate occur (Lansing M. Prescott et al. 1990, 1993, p. 120). Turbidostat- involves a photocell that measures the turbidity of the culture in the growth vessel. The rate of flow of the media through the growth vessel is automatically regulated to maintain a predetermined turbidity. Here the dilution rate remains constant and there is no limiting nutrient in the culture. The turbidostat operates best at high rates of dilution (Lansing M. Prescott et al. 1990, 1993, p. 120). Advantages of using continuous cultures: They allow good utilization of the bioreactor and ensure low labor costs (Nielsen Villadsen 1994, p. 344). They are efficient and ensure high and constant productivity due the autocatalytic nature of microbial reaction taking place (Nielsen Villadsen 1994, p. 344). They allow detailed analysis of microbial physiology at different growth rates as all cells of the population achieve a steady state and hence has significant industrial and research applications (Slonczewski Foster 2009, p. 139). The situation in a chemostat resembles the growth of bacteria in nature where the growth rates are very low (Slonczewski Foster 2009, p. 140). According to Xuezhen Kang (2000) their use eliminates the lag the organism experiences before going into high productivity. Disadvantages of using Continuous Cultures: Sometimes they fail to produce results due to infection and mutations of microorganisms that result in production of non producing strains (Nielsen Villadsen 1994, p. 344). Use of these cultures requires downstream equipments to be designed for low volumetric rates and continuous operation (Nielsen Villadsen 1994, p. 344). In conclusion, we see that both culture mediums have their advantages and disadvantages and while using either one, these should be kept in mind.

The Stresses of War Affecting the Characters in Regeneration and Journe

The Stresses of War Affecting the Characters in Regeneration and Journey's End 'Regeneration' is a fictional novel written by by Pat Barker. However, some of her characters in the novel like Owen and Sassoon did exist. The play 'Journeys End' is also fictional and all the characters are Sheriffs creation. 'Regeneration' is a serious and moving novel typical of war, as it shows war in a realistic way, whereas 'Journeys End' is full of black humour, in an attempt to make the play less morbid then it actually is. The writers are trying to achieve the views of the officers; they never actually saw mental ill health as serious as it was. They kept sending men back to war whether they had recovered or not. In the first chapter of 'Regeneration' we learn of the 'soldier's declaration' written by Sassoon. "I believe the war is being deliberately prolonged by those who have the power to end it". To other men in war this would be seen as "wrong and wimpish" because men weren't expected to do that, if you went to war you weren't seen as a coward. To Sassoon this declaration was the bravest thing he had ever done. For someone in war to write this they must have had enough and this shows the stress he was under. Barker could have used the declaration to portray her point on the futility of war. Another example of the stresses of war on Sassoon in the first chapter is when he throws away his medal for 'saving lives'. To receive a medal in war is widely regarded as a great honour to any man. Sassoon may have threw it away as he may feel that its ironic and degrading that he risks his and saves others lives, and all he gets in return is a medal. However, the beginning of 'Journey's End' is very different "he ca... ... learn of the death of Raleigh. Stanhope sits with him until he dies. Even though all of the soldiers are stressed about the war they still look after their men at times of need. This is in contrast with 'Regeneration' as Rivers looks after his men all throughout the novel, not just at times of need. "The point of the meeting is to protect the soldiers". In 'Regeneration' Burns leaves the hospital in an impulse, he doesn't know where he is going to go, or what he is going to do. His mental state is extremely fragile. Burns has desire for escape out of the hospital and away from human beings. This is in contrast with 'Journey's End' as Stanhope is ill but refuses to give up. "Young Stanhope goes on sticking it month in, month out". Considering all the stress that he is under, and how hard it must be, he is seen as being a bit of a hero to the audience.

Alcohol Use Disorders

The amount of written and published materials about alcohol and alcohol related disorders continue to grow everyday because the role of these written output is to chronicle how human society is moving forward alongside medical and psychological development that can handle the cases that come up in line with people and the psychological and mental dilemma they face after breaching the limits of excessive alcohol intake.Reflected in the paper are either opinions of specialists or products of intensive study in the part of the specialist.This paper is designed to capture as much information as possible that can lead to the continuation of the building block process required in the continued creation and improvement of socially shared knowledge, and today, Internet and magazine articles, private journals as well as news and professional journals in the field of medicine, psychiatry and psychology are consistently fulfilling the role they are designated for. Basically, the paper is geared so that people can know more.This paper gave a very short description about alcohol and its role in the society, as well as in our health – how it is being abused and taken in excess and what are its repercussions to health, especially in the mental soundness of a person. The paper included in its discussion the salient points of Kalapi's arguments and the newfound analysis on the changing behavior of college students and the fading concept of controlled drinking.The paper will also discuss published works and related stories about alcohol and anxiety disorder as well as kids who are suffering from ADHD and how alcohol intake can gravely affect them in their lives sooner or later.Mental health and alcohol intake and the impact of some of the drugs given to patients to cure mental problems and how it affects the patients are also discussed in the paper, along with concerns that involve alcohol and disorders in sleeping such as the sleep related breathing disorder or SRBD.Intr oduction – The Institute of Alcohol Studies labeled alcohol as the second most widely consumed psychoactive drug in the world because of the promise of the alcohol’s after effects.Since the beginning of the establishment of the sciences and field of medical specializations that are capable of studying and analyzing the impact of alcohol in the mental health of the people, the influx of inputs backed with medical and scientific proofs extracted through acceptable and reliable means have been consistent, enabling modern day professionals to constantly remind the people about the possible mental health risk they might face especially with uncontrolled intake of alcohol in huge dosages.Every year, new information about alcohol related disorders pertaining to mental health are made available, and the purpose of this paper is to provide a collated and descriptive database of the new and updated information about alcohol.According to an Institute of Alcohol Studies paper, pro blems on alcohol and mental health have a close relationship with each other, ‘people with mental health problems are at raised risk of alcohol problems and vice versa' (IAS, 2007). Something that has to do with this partly is because of the intertwined nature of the two.One of the most common reactions of mentally bothered individuals is to resort to a means wherein he or she is free to recreate the world, something which is easily done with the help of alcohol, while some excessive drinkers are experiencing an altered world because of the toxicity of the body from the high level of alcohol intake.There are many reasons why, and some of which may include the fact that alcohol intake for some is an act that can enable a person to cope with whatever problem he or she is experiencing at the moment, which includes depression, anxiety, obsessive-compulsive disorders, manic- depressive illness and even schizophrenia.Alcohol Related Disorders is one of the many disorders included in the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision, or simply the DSM-IV-TR.Indicated in the DSM-IV-TR under the topic Alcohol Related Disorders are several other sub topics that talk about alcohol related disorders, namely the following: Abuse, Dependence, Induced Anxiety Disorder, Induced Mood Disorder, Induced Persisting Amnestic Disorder, Induced Persisting Dementia, Induced Psychotic Disorder, With Delusions, Induced Psychotic Disorder, With Hallucinations, Induced Sexual Dysfunction, Induced Sleep Disorder, Intoxication, Intoxication Delirium, Related Disorder NOS, Withdrawal and Withdrawal Delirium.Because of the scope and breadth of the discussion alcohol related disorder, the paper will try its best to exhaust every possible source to bring to light updated and published works that present new and updated information regarding the development in the different fields of science that directly or indirectly affects one or every alcohol relat ed disorder topic.New Findings about Alcohol-Related Disorders – Alcohol, alcoholism and the resulting physical and social impact brought about by concerns stemming from the uncontrolled and unchecked use of alcohol is the reason why specialists in different fields are working non-stop in trying to find answers and remedies to prevailing questions and problems that directly involve alcohol consumption and alcoholism.Practicing professionals as well as academicians take an important role in the task of updating the data bank of the collective societal consciousness with regards to the newest information involving mental and psychological health and alcohol consumption and dependence.These information are sometimes handed over to the people in the next echelon who are capable of mass communication like media entities and school teachers and instructors, as well as health service personnel and non-government organizations that are geared in helping the society cope with the pers isting problem of alcoholism, trying to keep its impact on the society and its people (and their health) to a modest minimum.This paper is geared in presenting a collection of new and update findings that focuses and affects the problems on alcohol-related disorders in the hope that these new information can help the readers be more informed of such types of disorders, how they can be checked and detected, how it can be avoided and how it can be cured.The information included in this paper includes notes on the paper and talk of Elissavet Kapaki, through the work Alcoholic dementia: myth or reality? which was published online on 2006.Information about the published study of William R. Yates, M.D. on August 23, 2007 about Anxiety Disorders in the Emedicine WebMD website, as well as the useful information from Steven Gans, MD regarding the impact of alcohol and the risk of suffering from alcohol related disorders among children suffering from ADHD syndrome in the article published May of this year, are also included in this paper.The paper also notes how the increase in cases of excessive beer drinking among college students and how it impacts the students’ psychological frame of mind, as mentioned in the article ‘Binge drinking, pill abuse intensify at colleges’, a   March, 2007 article from the Associated Press and published by the search engine MSN in partnership with NBC (MSNBC).

Characteristics of Revenge Tragedy

The revenge play or revenge tragedy is a form of tragedy which was extremely popular in the Elizabethan and Jacobean eras. The best-known of these are Thomas Kyd's The Spanish Tragedy and William Shakespeare's Hamlet. The genre was first categorised by the scholar Fredson Bowers.Contents:Origins, conventions, and themesHistory.Influence.Film.References.Origins, conventions, and themesThe only clear precedent and influence for the Renaissance genre is the work of the Roman playwright and Stoic philosopher Seneca the Younger, perhaps most of all his Thyestes. It is still unclear if Seneca's plays were performed or recited during Roman times; at any rate, Elizabethan and Jacobean playwrights staged them, as it were, with a vengeance, in plays full of gruesome and often darkly comic violence. The Senecan model, though never followed slavishly, makes for a clear definition of the type, which almost invariably includes A secret murder, usually of a benign ruler by a bad person.A ghostly vi sitation of the murder victim to a younger kinsman, generally a son A period of disguise, intrigue, or plotting, in which the murderer and the avenger scheme against each other, with a slowly rising body count A descent into either real or feigned madness by the avenger or one of the auxiliary characters An eruption of general violence at the end, which (in the Renaissance) is often accomplished by means of a feigned masque or festivity A catastrophe that utterly decimates the dramatis personae, including the avenger Both the stoicism of Seneca and his political career (he was an advisor to Nero) leave their mark on Renaissance practice.In the English plays, the avenger is either stoic (albeit not very specifically) or struggling to be so; in this respect, the main thematic concern of the English revenge plays is the problem of pain. Politically, the English playwrights used the revenge plot to explore themes of absolute power,  corruption in court, and of factional concerns that applied to late Elizabethan and Jacobean politics as they had to Roman politics.HistorySome early Elizabethan tragedies betray evidence of a Senecan influence; Gorboduc (1561) is notable in this regard. The â€Å"hybrid morality† Horestes (1567) also offers an early example of the genre.[1] Thomas Kyd's The Spanish Tragedy, however, is the first major example of the revenge plot in English drama. First performed 1587 and subsequently published in 1592, The Spanish Tragedy was a popular smash so successful that, with Tamburlaine, it practically defined tragic dramaturgy for a number of years.Refitted with additions by Ben Jonson, it found performance intermittently until 1642. Its most famous scenes were copied, transformed, and—finally—mocked; the play itself was given a sequel that may have been partially written by Kyd. Hamlet is one of the few Shakespeare plays to fit into the revenge category; indeed, it may be read as a figural, literary response to Kyd, wh o is sometimes credited with the so-called ur-Hamlet with which Shakespeare worked.As regards revenge tragedy, Hamlet is notable for the way in which it complicates the themes and deepens the psychology of its models. What is, in The Spanish Tragedy, a straightforward duty of revenge, is for Prince Hamlet, both factually and morally ambiguous. Hamlet has been read, with some support, as enacting a thematic conflict between the Roman values of martial valor and blood-right on the one hand, and Christian values of humility and acceptance on the other. Some academics would also argue the Othello could fit into the category of revenge.A more purely Jacobean example than Hamlet is The Revenger's Tragedy, apparently produced in 1606 and printed anonymously the following year. The author was long assumed, on somewhat unconvincing external evidence, to be Cyril Tourneur; in recent decades, numerous critics have argued in favour of attributing the play to Thomas Middleton. On stylistic groun ds, this argument is convincing.The Revenger's Tragedy is marked by the earthy—even obscene—style, irreverent tone, and grotesque subject matter that typifies Middleton's comedies. The play, though it lacks a ghost, is in other respects a sophisticated updating of The Spanish Tragedy, concerning lust, greed, and corruption in an Italian court. Caroline instances of the genre are largely derivative of earlier  models and are little read today, even by specialists.InfluenceA number of plays, from 1587 on, are influenced by certain aspects of revenge tragedy, although they do not fit perfectly into this category. Besides Hamlet, other plays of Shakespeare's with at least some revenge elements are Titus Andronicus, Julius Caesar, and Macbeth. Other revenge tragedies include The White Devil, Hoffman,The Changeling, The Duchess of Malfi, The Atheist's Tragedy, The Revenger's Tragedy, The Jew of Malta, The Revenge of Bussy D'Ambois, The Malcontent, Antonio's Revenge, The Du ke of Milan, The Maid's Tragedy, Valentinian, The Bloody Brother, ‘Tis Pity She's a Whore†, The Maid's Revenge, and The Cardinal.Thomas Pynchon's novel The Crying of Lot 49 contains an extended parody of the Jacobean revenge-play formula, titled The Courier's Tragedy and written by the fictitious Richard Wharfinger. Most of the action is simply described by the narrator, with occasional snippets of dialogue. In Edward Gorey's masterpiece, The Unstrung Harp, the protagonist, the novelist Mr Earbrass, sees a performance of Prawne's The Nephew's Tragedy, a fictional revenge play performed, â€Å"†¦ for the first time since the early seventeenth century, by the West Mortshire Impassioned Amateurs of Melpomene.†

A Biography of Roger B. Chaffee, NASA Astronaut

A Biography of Roger B. Chaffee, NASA Astronaut Roger Bruce Chaffee was born on February 15, 1935. His parents were Donald L. Chaffee and Blanche May Chaffee. He grew up with an older sister in Greenville, Michigan until the age of 7 when the family relocated to Grand Rapids for Donald Chaffees job with the Army. Fast Facts: Roger B. Chaffee Name: Roger Bruce ChaffeeBorn: February 15, 1935 in Grand Rapids, MIDied: January 27, 1967, in the Apollo 1 fire at Kennedy Space CenterParents: Donald Lynn Chaffee, Blanche May ChaffeeSpouse: Martha L. HornChildren: Sheryl Lyn and Stephen.Career: Served in the Navy until his selection as a NASA astronaut in 1963  Education: Air Force Institute of Technology, Purdue UniversityHonors: Congressional Medal of Honor and Navy Air Medal (both posthumous) Chaffee entered the Illinois Institute of Technology as a Naval Reserve Officer Training Corps (NROTC) candidate and transferred to Purdue University in 1954, where he studied aeronautical engineering. While there, he entered flight training and qualified as an aviator. Upon graduation, Chaffee finished his Navy training and entered the service as an ensign. He married Martha Louise Horn in 1957 and they had two children. While in the Navy, Chaffee continued flight training in Florida, first at Pensacola and later at the Naval Air Station in Jacksonville. Throughout his time there, he logged 2,300 hours of flight time, with much of that occurring in jet aircraft. He was awarded a Navy Air Medal for his work in photographic reconnaissance during his Navy career. Chaffees Career at NASA Early in 1962, Roger Chaffee applied to the NASA astronaut program. Accepted initially, he worked on a masters degree at the U.S. Air Force Institute of Technology at Wright-Patterson in Ohio while waiting for the final determination. Chaffees area of study was in reliability engineering, and while there he also continued adding to his flight log. In 1963 he was selected as an astronaut and began training as part of the third group of astronauts ever chosen.   Portrait of Astronaut Roger B. Chaffee. NASA Johnson Space Center (NASA-JSC) Chaffee was assigned to the Gemini program and worked as the capsule communications specialist (CAP com) for Gemini 4. He worked on deep space instrumentation equipment and its use. While he never flew a Gemini mission, he was an essential part of the team. Eventually, Chaffee was assigned to Apollo 1, which was then called AS-204 (for Apollo-Saturn). It was scheduled to fly early in 1967.   The crew of Apollo 1 at Launch Complex 34, Virgil I. Gus Grissom, Ed White, and Roger Chaffee. NASA The Apollo 1 Mission The Apollo program was the series of flights that would eventually lead to astronauts landing on the Moon. For the first mission, the astronauts would test all the spacecraft systems, along with ground-based facilities for tracking and communications. Chaffee, who was familiar with all the Gemini systems, began training with the Apollo engineers in order to understand the capsules capabilities. This included a long series of simulations that led up to what the team called a plugs-out countdown demonstration. This simulation included the astronauts being fully suited up and in the capsule as if it were in flight configuration. This took place on January 27, 1967, and Chaffees role on the mission would be as chief communications expert with the engineers and team members in the mission blockhouse.   All went well until several hours into the mission, when a power surge created an electrical short inside the capsule. That ignited a fire in the capsule materials. The blaze was so intense and hot that it overcame the astronauts while they were trying to escape. Roger Bruce Chaffee and his teammates Gus Grissom and Edward White were all killed in the space of a minute. Later investigation showed that the bare wires and the oxygen-rich atmosphere inside the capsule contributed to the strength of the blaze. It was a huge loss for the space program and focused the nations attention on astronauts and the dangers they face, leading to a major revamp of the capsule interior and hatch for future missions. Apollo 1 and the aftermath of the fire. NASA Headquarters - GReatest Images of NASA (NASA-HQ-GRIN) Honors for Roger Chaffee Roger Chaffee was buried at Arlington National Cemetery, along with teammate Gus Grissom. Edward White was buried at West Point.  Chaffee was honored with a second Air Medal by the Navy after his death, along with the Congressional Medal of Honor. He is memorialized in the International Space Hall of Fame in Alamogordo, NM, as well as the U.S. Astronaut Hall of Fame in Florida. His name appears on a school, a planetarium, and other facilities, and there is a statue of him in Grand Rapids at the Childrens Museum.   Sources NASA, NASA, www.jsc.nasa.gov/Bios/htmlbios/chaffee-rb.html.NASA, NASA, history.nasa.gov/Apollo204/zorn/chaffee.htm.Voskhod 2, www.astronautix.com/c/chaffee.html.

Free Essays on Comparing And Competing

When I was in elementary school, our classes would compete in sales of Christmas cards as a fundraiser for various equipment and supplies. The winning class received an ice cream party, and the student acquiring the most sales won a special award. Being quite competitive, I found myself challenged by a boy in another classroom. I worked very hard making phone calls to all my relatives, knocking on doors in my neighborhood, and even begging for sales at my church. â€Å"Marco’s† family, however, was affluent, and she didn’t have to exert much effort selling his cards. His parents just purchased the whole case of cards and that was the end of that. I took this as a personal affront and I began to compare myself to him and my family to his. The next year, the big finale was a history contest in the library that showcased on the final contestants: Marco and me. I had great hopes that our class would win. Then I learned that Marco knew that father of Alexander the Great had only one eye and I had missed that. His intelligence loomed before me, merging with my already tainted image of his perfect little self and â€Å"financially privileged† family (as I thought of them). As for me, I had become frustrated, discouraged, and depressed with the faulty images of my life I had accepted. I was uncertain about my future and whether or not I would ever amount to anything of value to anyone. I had worked so hard to win approval- to be like Marco- but I had failed, at least in my own heart. I just didn’t measure up to my own expectations. If I couldn’t be like him, then who was I? Out of desperation I shared my struggles with my grandmother, Zorka. She told me that I did not have to be like anyone else on earth; that she loved me for who I was. She, also, said not to limit my possibilities by what I see in someone else's life or what others expect of me. The anger and bitterness began to melt away Gradually; I let go of compar... Free Essays on Comparing And Competing Free Essays on Comparing And Competing When I was in elementary school, our classes would compete in sales of Christmas cards as a fundraiser for various equipment and supplies. The winning class received an ice cream party, and the student acquiring the most sales won a special award. Being quite competitive, I found myself challenged by a boy in another classroom. I worked very hard making phone calls to all my relatives, knocking on doors in my neighborhood, and even begging for sales at my church. â€Å"Marco’s† family, however, was affluent, and she didn’t have to exert much effort selling his cards. His parents just purchased the whole case of cards and that was the end of that. I took this as a personal affront and I began to compare myself to him and my family to his. The next year, the big finale was a history contest in the library that showcased on the final contestants: Marco and me. I had great hopes that our class would win. Then I learned that Marco knew that father of Alexander the Great had only one eye and I had missed that. His intelligence loomed before me, merging with my already tainted image of his perfect little self and â€Å"financially privileged† family (as I thought of them). As for me, I had become frustrated, discouraged, and depressed with the faulty images of my life I had accepted. I was uncertain about my future and whether or not I would ever amount to anything of value to anyone. I had worked so hard to win approval- to be like Marco- but I had failed, at least in my own heart. I just didn’t measure up to my own expectations. If I couldn’t be like him, then who was I? Out of desperation I shared my struggles with my grandmother, Zorka. She told me that I did not have to be like anyone else on earth; that she loved me for who I was. She, also, said not to limit my possibilities by what I see in someone else's life or what others expect of me. The anger and bitterness began to melt away Gradually; I let go of compar...

Top French Pronunciation Mistakes and Difficulties

Top French Pronunciation Mistakes and Difficulties Many students find that pronunciation is the hardest part of learning French. The new sounds, the silent letters, the liaisons - they all combine to make speaking French very tricky. If you really want to perfect your French pronunciation, your best option is to work with a native French speaker, preferably one who specializes in accent training. If that isnt possible, then you need to take things into your own hands by listening to French as much as possible, and by studying and practicing the pronunciation aspects that you find most difficult. Here is a list of the top French pronunciation difficulties and mistakes, with links to detailed lessons and sound files. The French R The French R has been the bane of French students since time immemorial. OK, maybe its not quite that bad, but the French R is pretty tricky for a lot of French students. The good news is that it is possible for a non-native speaker to learn how to pronounce it. Really. If you follow my step-by-step instructions and practice a lot, youll get it. The French U The French U is another tricky sound, at least for English speakers, for two reasons: its hard to say and its sometimes difficult for untrained ears to distinguish it from the French OU. But with practice, you can definitely learn how to hear and say it. Nasal Vowels Nasal vowels are the ones that make it sound like the speakers nose is stuffed up. In fact, nasal vowel sounds are created by pushing air through the nose and mouth, rather than just the mouth as you do for regular vowels. Its not so difficult once you get the hang of it - listen, practice, and you will learn. Accents French accents do more than just make words look foreign - they modify pronunciation and meaning too. Therefore, its extremely important to know which accents do what, as well as how to type them. You dont even need to buy a French keyboard - accents can be typed on virtually any computer. Silent Letters Many French letters are silent, and a lot of them are found at the end of words. However, not all final letters are silent. Confused? Read over these lessons to get a general idea of which letters are silent in French. H  Muet  / Aspirà © Whether its an  H  muet  or an  H aspirà ©, the French H is always silent, yet it has a strange ability to act as a consonant or like a vowel. That is, the  H aspirà ©, although silent, acts like a consonant and does not allow contractions or liaisons to occur in front of it. But the  H  muet  acts like a vowel, so contractions and liaisons are required in front of it. Confusing? Just take the time to memorize the type of H for the most common words, and youre all set. Liaisons and Enchaà ®nement French words flow one into the next thanks to liaisons and enchaà ®nement. This causes problems not only in  speaking but in  listening comprehension  as well. The more you know about liaisons and enchaà ®nement, the better youll be able to speak and understand whats being spoken. Contractions In French, contractions are required. Whenever a short word like  je, me, le, la, or  ne  is followed by a word that begins with a vowel or H  muet, the short word drops the final vowel, adds an apostrophe, and attaches itself to the following word. This is not optional, as it is in English - French contractions are required. Thus, you should never say je  aime or le  ami - it is always  jaime  and  lami. Contractions  never  occur in front of a French consonant (except H  muet). Euphony It may seem odd that French has specific rules about ways to say things so that they sound prettier, but thats the way it is. Familiarize yourself with the various euphonic techniques so that your French sounds pretty too. Rhythm Ever heard anyone say that French is very musical? Thats partly because there are no stress marks on French words: all syllables are pronounced at the same intensity (volume). Instead of stressed syllables or words, French has rhythmic groups of related words within each sentence. Its kind of complicated, but if you read my lesson youll get an idea of what you need to work on.

Women Rights Research Paper Example | Topics and Well Written Essays - 1000 words

Women Rights - Research Paper Example Before 1877, it was unthinkable for a woman to leave her house and cater to issues concerning work or politics. Women’s roles were strictly those of taking care of their families at home. It has taken along battle characterized with hard work and determination for the women of today to enjoy the same rights as men. Since the beginning of the contemporary world, a woman has had a unique role in society: that of being a source of human life. Nonetheless, historically, women have been seen as inferior to men, intellectually, physically, sexually, and otherwise. In addition, women are always associated with evil and temptation, a notion possibly derived from the biblical scriptures of Adam and Eve in the Garden of Eden. For instance, early Roman laws viewed women as children, while the Greek mythology suggests that it was a woman (Pandora) who brought unhappiness and plague to humankind by opening the forbidden box1. Before 1800s, women could not own property, vote, get equal educ ation as men, or get involved in political issues. Some of the early female philosophers include Olympe de Gouges with the publication ‘declaration of women rights’ protesting against the failure of revolutionists in mentioning women in their declaration of human rights. There was Margret Fuller, a female reporter who wrote the article ‘Women in the Nineteenth century’ around 1845. The leader of women rights in America, Elizabeth Candy Stanton, was a major figure in the women rights movement. In addition, there was also Charlotte Perkins Gilham, Clara Barton among others2. The first known women rights movement began in 13, July 18483. A tea conversation between Elizabeth Candy Stanton and other four women friends turned to women issues, with emphasis on women’s roles in the American Revolution and their then lack of freedom4. This afternoon conversation was the first group of women fighting for their rights, and the first to organize specific, extens ive programs that called for review of women rights in America. Two days after the formation of the small group, they had set a date for their first convention. The location of choice was the Wesleyan Chapel in Seneca Falls, setting the date to 19 and 20, July 1848. The Seneca County Courier carried the announcement for the convention. This was the first ever-public meeting of its king in western civilization. According to these women, they were patriotic members of the society trying to share the ideas that would improve the new republic by heeding the promise of providing a more egalitarian life for all its citizens. As the women were preparing and waiting for the first convention, Elizabeth Candy Stanton was applying the Declaration of Independence framework to design the â€Å"Declaration of Sentiments† for the women rights movement. In complete resemblance to the important American symbol of liberty, Stanton was able to connect the Declaration of Independence to the figh t for women’s rights. Stanton’s draft carefully listed a number of areas where women were most treated unjustly, eighteen in number. The words that Stanton used to express women grievances were strong words expressing large grievances but nonetheless filling the American atmosphere with the hope of a bright future for women. The two days convention began on July 19, 1848, and was successful. The discussions at the convention resulted in several major endorsements of the declarations of sentiments and twelve resolutions with a few amendments. Among the resolutions were the rights to equal laws, and equal job and education opportunities. The only two resolutions that failed to pass were the women’s right to vote in elections and their enfranchisement. Despite their grievances and achievements on the convention,

Essay 3 Example | Topics and Well Written Essays - 250 words - 3

3 - Essay Example In the environment, particularly one such as an island, most of the ecological niches are usually unoccupied. In the new ecosystem, the species have to evolve and adapt first if they want to survive. In the process of adapting, the species may change so much that in the end it becomes a different species. This is when the species is said to be going through convergent evolution. Convergent evolution refers to the process where unrelated species evolve into similar uniqueness the due to environmental pressures (Wilson 100). Therefore, the process of adaptive radiation takes place when the new species has to evolve so as to make use of the available ecological niches. It is crucial to note that adaptive radiation occurs when the species are under high pressure in the new environment. It is also crucial to note that when adaptive radiation occurs speciation does not take place consciously (Wilson 118). In speciation process, new species are formed. Animals in the new environment are never conscious when adapting into new species. Additionally, in the environment, evolutionary development of adaptive radiation only occurs mostly in animals and a few times in plants. This is because plants do not disperse in new environments like the

Exercises BYP10-1 and BYP11-10 Essay Example | Topics and Well Written Essays - 1000 words

Exercises BYP10-1 and BYP11-10 - Essay Example ‘Write the press release convincing the stockholders that the stock dividend is just as good as a cash dividend’, he orders. ‘Just watch our stock rise when we announce the stock dividend; it must be a good thing if that happens.’ There is nothing unethical about President Mailor’s actions, as declaring dividends are at the sole discretion of the company. Moreover, Greenwood has paid out cash dividends for over 15 years, when the company was doing better in terms of cash as well as earnings. At the time of crisis, where there is only enough liquid assets to take care of day - to – day operational activities, the decision taken by President Mailor is very reasonable. When stock dividends are declared, the stockholders are given additional stocks based on the number of stocks originally held by them. If this involves, adding new shares to the company, then the total number of stocks are increased; however the value of the stock is reduced, so that the total stockholders’ equity remains the same. Hence a stock dividend increases the number of stocks whereas the total value of stockholder equity is unchanged. As a stockholder, a cash dividend is preferred, as it is paid out immediately and adds value to the stockholder. However a stock dividend is of lesser value to the stockholder, as it just increases the number of stocks held and does not add value immediately. The stock dividend appreciates only when the value of the company goes up in the future. But there is also a possibility of the company’s value going down. Hence a cash dividend is more preferred by the

Conflict Scenario PowerPoint Presentation Example | Topics and Well Written Essays - 1250 words

Conflict Scenario - PowerPoint Presentation Example The template given to the receptionist by the doctor could be a standard template but the template given by the scheduler may not be the standard one and so the scheduler gave a patient an appointment that does not exist. This led to confusion even to the doctor. The scheduler could have reduced the whole chaos if her personal attitude would have notcome her way when discussing with the receptionist. Due her attitude she disliked to talk to the receptionist and about the issue to resolve and instead she left a blind eye on the issue, which led to all the problems. Due to this unacceptable attitude towards work by the scheduler the issue could not have escalated and could have been subsided. Typically, entry-level nursing education programs provide some basic exposure to general and basic breast cancer nursing, but little direct experience in patient care and scheduling process should be offered. Academic programs in patient care nursing are generally restricted to graduate advanced practice programs for clinical nurse specialists or nurse practitioners. The perception of understanding has a great deal to do with communication and managerial effectiveness. Since outstanding management presumes that one can influence people to be communicative, an objective analysis of your influencing capacities and the way other people see it is crucial. One way to get this kind of necessary feedback is to take an interactive and intense program to help accomplish a critical self-assessment. Examine interpersonal intangibles in that setting. Experiment with and examine the present interactive style and refine and improve it - in response to the straightforward and frank feedback that you receive. Arrange, somehow, if possible, to get out of the daily work situation into a relaxed, informal setting with a small group of other staff and executives. Talk to each other. Discover ways in which ones behavior and attitudes affect others. Put oneself in the capable hands of a qualified professional trainer. Cover this in training seminar such things as listening, communicating, leading, handling frustration and anger, asserting yourself, facing pressures, relating to colleagues, personal openness, handling stress, perceiving, respecting other people's feelings, selling your ideas to other people, and giving and receiving constructive critici sm. After getting to know each other quite well, formally and informally, near the end of the program have a major feedback session. Then the group discusses: whether or not, based on what they have got to know about you at that point, they would want you as a colleague and why or why not. Flexibility The increasing complexity of pediatric critical care has required a corresponding evolution in the sophistication of pediatric critical care nursing (PCCN). The role of the nurse in this setting is multifaceted. First, the nurse serves as a form of total systems monitor-continually examining all the physiologic monitors and treatment devices, along with the child's body. This requires the acquisition of peripheral vision. A skilful doctor learns to adjust settings on critical care equipment so it can serve as an extension of his or her own sensory system. The nurse has to perform routine maintenance activities (e.g., medication preparation, blood procurement) while

Growth of the World's Cities - Seattle, Washington, United States Assignment

Growth of the World's Cities - Seattle, Washington, United States - Assignment Example The Seattle metropolitan area has more than 3.6 million inhabitants making the metropolitan area. The significant growth of the city’s population has negatively affected how the city settles its residents. In 2006, after the city grew by more than 4000 residents per year, the Seattle regional planners thought of expanding the city to accommodate the increasing population (Singh, 28). The City of Seattle, which is a Historical Core Municipality, grew 8.0 percent from 564,000 in 2000 to 609,000 by 2010. This means that the area experienced a healthy increase. The modern-day Seattle is completely different from the historical Seattle. The expansion of the city and the population in the metropolitan area has been intense (Singh, 45). Currently, Seattle city now constitutes to less than 15% when it comes to the metropolitan region population. In 1950, Seattle city had almost two-thirds of King County population and by 2010, the city was less than a third of the population in King County. While the city has continued to reduce in terms of the region’s population, the downtown region is losing its impressive dominance. By 2009, the area had fallen to 8% in terms of the region’s employment (Diers, 32). The inner suburbs thus the areas that are outside the Seattle city account for almost 90 percent in terms of growth. Inner suburbs in the metropolitan region include the Eastern, southern and the northern part of the King County. These regions experienced 50% of growth thus 1,170,000 to almost 1,320,000. At least 150,000 new residents resided in the area. On the other hand, the outer suburbs areas, which include the Snohomish and the Pierce County, grew 15.4 percent thus nearly double Seattle growth. Alternatively, the exurban areas growth rates almost resembled the outer suburbs growth whereby the population of these areas grew by almost 15 percent (Singh, 76). Most of the urban and population growth in the Seattle region is associated with the need for people to have jobs and a better life.  Ã‚  

Capstone Essay Example | Topics and Well Written Essays - 2000 words - 8

Capstone - Essay Example This paper also provides information concerning the ethical values of the company, and how it affects the organizations bottom line. Northrop Grumman is an American Multi-national company, specializing in the production of defense and aerospace facilities/ products. The company began its operations in 1994, through an acquisition of Northrop by Grumman. As of the year 2010, this company was voted as the fourth largest defense contractor in the world, and it employs more than 68,000 employees all over the world. The mission of the company is to be a leader in the production of defense and aeronautical technology. The mission of the company is also to satisfy the various needs of its customers through delivery and innovating high quality technological products, which are affordable (Hayden, Campbell and Cummins, 2010). The vision of the company on the other hand is to be a trusted and reliable supplier and producer of technologies and systems capable of protecting the country. To achieve this objective, the company aims to observe ethical values that guide defense contracting, promote innovation and collaboration a mongst its employees and key stakeholders. The key stakeholders of Northrop Grumman are share holders, suppliers, employees, and the company’s customers, which are always security institutions of America, and American allies. These people have an impact on the general performance of the company; this is because the company aims at achieving profitability for purposes of satisfying its shareholders and customers (Hayden, Campbell and Cummins, 2010). The company also seeks to produce high quality defense technologies, for purposes of protecting the country and satisfying the needs of its customers. Production of high quality defense technology is part and parcel of the organization’s mission and vision, and hence the employees of the

Growth of the World's Cities - Seattle, Washington, United States Assignment

Growth of the World's Cities - Seattle, Washington, United States - Assignment Example The Seattle metropolitan area has more than 3.6 million inhabitants making the metropolitan area. The significant growth of the city’s population has negatively affected how the city settles its residents. In 2006, after the city grew by more than 4000 residents per year, the Seattle regional planners thought of expanding the city to accommodate the increasing population (Singh, 28). The City of Seattle, which is a Historical Core Municipality, grew 8.0 percent from 564,000 in 2000 to 609,000 by 2010. This means that the area experienced a healthy increase. The modern-day Seattle is completely different from the historical Seattle. The expansion of the city and the population in the metropolitan area has been intense (Singh, 45). Currently, Seattle city now constitutes to less than 15% when it comes to the metropolitan region population. In 1950, Seattle city had almost two-thirds of King County population and by 2010, the city was less than a third of the population in King County. While the city has continued to reduce in terms of the region’s population, the downtown region is losing its impressive dominance. By 2009, the area had fallen to 8% in terms of the region’s employment (Diers, 32). The inner suburbs thus the areas that are outside the Seattle city account for almost 90 percent in terms of growth. Inner suburbs in the metropolitan region include the Eastern, southern and the northern part of the King County. These regions experienced 50% of growth thus 1,170,000 to almost 1,320,000. At least 150,000 new residents resided in the area. On the other hand, the outer suburbs areas, which include the Snohomish and the Pierce County, grew 15.4 percent thus nearly double Seattle growth. Alternatively, the exurban areas growth rates almost resembled the outer suburbs growth whereby the population of these areas grew by almost 15 percent (Singh, 76). Most of the urban and population growth in the Seattle region is associated with the need for people to have jobs and a better life.  Ã‚  

Article Analysis Example | Topics and Well Written Essays - 500 words - 3

Analysis - Article Example To argue this point Hardin develops the thesis of the tragedy of the commons as being borne out of a system that treats the public domain as something that is self-correcting to stasis, and that man works in accordance with what seems to be selfish interests but are in fact actions that in the end work toward the good of all. The tragedy of the commons is the idea that society and people seem blindsided by an appeal to the commons as something that is to be had by all, even when the commons that is referred to here, whether food, or land, or the ability of the environment to take in pollution and waste, are finite things. Hardin essentially says that in fact the individual cannot be trusted to work for the common good, and that society, hardwired as it is to treat the commons as something that is unlimited in supply, is in effect perpetually in a course to deplete the commons and to wreak havoc on the very same things that sustain it. Hardin essentially says that in a world of explod ing populations there is less and less room for the notion of the commons as something that can be exploited and used without restraint or conditions. This outdated notion worked when the populations were low and the actions of men individually and collectively had little effect on the quality and availability of those common things, in the same way that adding a pinch of salt to a glass of water would not alter the taste of the water substantially, but adding more and more salt would eventually change the character of the water and its taste fundamentally. This is the same with the commons and the way the commons has been conceived and abused by society. This old notion of the inexhaustible nature of the commons must go, according to Hardin. Already he says, there have been curbs set in place with regard to the land and the tilling and grazing of the land; in the disposal of

Current Diagnostic Methods for Human Immunodeficiency Virus

Current Diagnostic Methods for Human Immunodeficiency Virus Abstract: Detection of human immunodeficiency virus (HIV) infection is essential for diagnosis and monitoring of the infection. There are several different types of diagnostic tools available that are based on detection of HIV-specific antibodies, virus antigen, or nucleic acid. Sensitivities and specificities of assays utilized for HIV detection have improved. Newer HIV testing technologies such as third-generation enzyme immunoassay (EIA) which detect HIV-specific IgG and IgM antibodies, fourth-generation EIA which detect both anti-HIV antibodies and HIV p24 antigen, and nucleic acid-based tests (NATs) for HIV RNA, have significantly decreased the window period. This review study provides an overview of current technologies for the detection and monitoring of HIV infection and recent advances in the field of HIV diagnosis. Keywords: HIV diagnosis; HIV antibody test; human immunodeficiency virus; Immunoassay; Polymerase chain reaction (PCR) Introduction: Diagnosis of HIV infection contributes to evaluating the progression of disease, monitoring the effectiveness of antiretroviral therapy (ART), and prevention and control of HIV/AIDS. The diagnosis of HIV is associated with decrease in risky behaviors, reduced HIV transmission, and improved survival linked to increased case detection, earlier care and treatment. HIV-negative persons can also protect themselves from HIV when making sexual decisions by engaging in safer sex behaviors and sometimes, taking pre-exposure prophylaxis (PrEP). Early diagnosis of HIV infection provides an opportunity for risk reduction counseling and preventing further transmission of the disease, while late diagnosis of HIV infection is detrimental to infected patients and to the public health, and is associated with an increased rate of morbidity, mortality, and healthcare costs. Since the start of the epidemic, it is estimated that 78 million people have become infected with HIV and 35 million people have died from AIDS-related illnesses. In 2015, 2.1 million people became newly infected, 36.7 million people were living with HIV and 1.1 million people died from AIDS-related illnesses. New HIV infections have fallen by 6% since 2010. Sub-Saharan Africa, which bears the heaviest burden of HIV/AIDS worldwide, accounts for 65% of all new HIV infections. Other regions significantly affected by HIV/AIDS include Asia and the Pacific, Latin America and the Caribbean, and Eastern Europe and Central Asia (Table 1) [9]. The present study aims to conduct a narrative review to summarize and discuss the current diagnostic methods for HIV and recent developments. We start with a brief overview of HIV infection, follow by a description on the development of virological and immunological markers following HIV infection. Thereafter, we introduce current algorithms for laboratory HIV testing with different kind of current diagnostics techniques including various generations of enzyme immunoassays, rapid or point-of-care tests, and qualitative/quantitative PCR assays. Overview of HIV Infection: HIV-1 causes chronic infection which is usually characterized by progressive immune deficiency, a long period of clinical latency, and appearance of opportunistic infections [1, 2]. Characteristics of HIV include infection and viral replication in T lymphocyte expressing CD4 antigen. Qualitative defects in CD4 cell response and a gradual decline in their numbers increase the risk of opportunistic infections like Pneumocystis carinii pneumonia, and neoplasms such as Kaposis sarcoma and lymphoma [3-5]. HIV infection can disrupt functions of blood monocytes, tissue macrophages, and B lymphocytes, and also increase the potential of encapsulated bacteria for developing infections [6, 7]. Direct invasion of CD4 cells in the peripheral and central nervous systems can cause meningitis, peripheral neuropathy, and dementia [8]. The prognosis is variable between people infected with HIV-1. In adults, the average time between HIV exposure to AIDS stage is 10-11 years, but a remarkable proportion of individuals (~20%) progresses rapidly to AIDS within 5 years after HIV exposure. On the other hand, it is estimated that 12% of infected individuals will remain free of AIDS for 20 years [10]. Prophylaxis and in particular antiretroviral therapy (ART) significantly enhanced the overall prognosis of HIV disease against opportunistic infections [11]. The most common route of HIV infection is sexual transmission at the genital mucosa via direct contact with infected body fluids, such as blood, semen, and vaginal secretions. Infection may also occur via inoculation of infected blood, transfusion of infected blood products, transplantation of infected tissues, from an infected mother to her infant during pregnancy, or by reuse of contaminated needles [12]. The probability of transmission after a single exposure with an uncontrolled HIV source has been estimated to be 1/150 with needle sharing, 1/300 with occupational percutaneous exposure, 1/300-1/1000 with receptive anal intercourse, 1/500-1/1250 with receptive vaginal intercourse, 1/1000-1/3000 with insertive vaginal intercourse, and 1/3000 with insertive anal intercourse. The average risk is 12-50% for congenital (mother-to-child) transmission, 12% for breast-feeding, 90% for a contaminated blood transfusion, and 0.1-1.0% for nosocomial transmission [13]. The risk of HIV transmission during early or acute HIV infection appears to be greater than during chronic infection (251). Available data suggest that the viral load is an important predictor of the risk of heterosexual transmission, and patients with levels less than 1500 copies of HIV-1 RNA per milliliter are at lower risk of HIV transmission, whereas the probability of transmission is increased dramatically with increasing vira l loads (250). Laboratory markers for HIV-1 infection: Several immunological and virological blood markers can be monitored during the course of HIV infection. These markers appear highly consistent between different individuals in a chronological order and allows classification of HIV infection into distinct laboratory stages including eclipse period, seroconversion window period, acute HIV infection, and established HIV infection (Figure 1) [14, 15]. Shortly after exposure to HIV-1, no viral markers are consistently detectable in plasma, but low levels of HIV-1 RNA can be found intermittently [16]. This period is called the eclipse phase. About 10 days after infection, HIV-1 RNA becomes detectable by NAT in plasma and quantities rise to very high levels [17], which subsequently decline rapidly until reaching a set point, a stable level that may persist for years. This stable level of HIV RNA represents an equilibrium between HIV and host immune responses and is an important indicator of subsequent disease progression, and potential transmission of HIV. It has been shown that the higher HIV-1 RNA plasma level is associated with faster progression to AIDS [18]. The set point plasma HIV-1 RNA level can be a helpful clinical tool for determining the timing of initiation of antiretroviral therapy for HIV-infected patients. For instance, patients with high set point levels can be started on aggressive antiretroviral therapy and patient s with low set point levels can be monitored without initiating therapy [19]. HIV-1 p24 antigen is expressed and quantities rise to levels that can be measured by fourth-generation immunoassays within 17 days after infection (typical range 13-28 days) [15, 20]. Due to high titers of p24 antigen present in the sera of acutely infected patients during the interval prior to seroconversion, p24 Ag assay can be utilized to diagnose the primary HIV-1 infection [21]. Nevertheless, detection of p24 antigen is transient because, as antibodies begin to develop, they bind to the p24 antigen and form immune complexes that interfere with p24 Ag assay [22, 23]. The time interval between infection with HIV and the first detection of antibodies is known as the serological window period. The detection of HIV-specific antibodies indicates the end of the window period and the individual is known as seropositive [24]. The length of the window period depends on the design and the sensitivity of the immunoassay. Expression of IgM antibodies can be detected by immunoassays within 10 to 13 days after the appearance of viral RNA, 3 to 5 days after detection of p24 antigen, and peak between the 4th and the 5th week [15, 20, 25, 26]. Thereafter, the emergence of IgG antibodies occurs at about 3-4 weeks after infection and persist throughout the course of HIV infection [21]. Nevertheless, the immune responses are highly dependent on the ability of the individuals immune system to produce the antibodies. Approximately, 50% of patients within 3-4 weeks and about 100% of them within 6 months have detectable antibodies, although there are reports indicating that a small percentage of patients may require up to 6 months for the appearance of antibodies [27]. Laboratory HIV testing algorithms: Since 1989, the diagnostic algorithm for HIV testing recommended by CDC and the Association of Public Health Laboratories (APHL) relied on the confirmation of a repeatedly reactive HIV immunoassay with the more specific HIV-1 antibody test, either the HIV-1 Western blot or HIV-1 indirect immunofluorescence assay (IFA). The Western blot was previously considered to be the gold standard for the diagnosis of HIV infection by Clinicians [29, 30]. It should be noted that both the Western blot and IFA are first-generation assays that detect only IgG antibodies against HIV proteins. Retrospective testing of specimens from high-risk individuals pointed that antibody testing alone may miss a significant percentage of HIV infections detectable by virologic tests such as HIV antigen and nucleic acid assays. In 2013, the CDC and the APHL released new guidelines on HIV testing that have led to the earlier diagnosis of HIV infection when compared with the previous diagnostic algorithm. The new recommended algorithm starts with a fourth-generation HIV-1/2 Ag/Ab immunoassay to screen for HIV infection that detects both HIV-1/2 antibodies and the HIV-1 antigen. When the result of initial immunoassay is nonreactive, further testing is not required for samples. Instead, testing with an HIV-1/HIV-2 antibody differentiation test is needed when the sample is reactive on the screening fourth-generation assay. Reactive results with the initial fourth-generation assay and the HIV-1/HIV-2 antibody differentiation immunoassay should be considered as reactive for HIV-1 antibodies, HIV-2 antibodies, or HIV antibodies, undifferentiated. Reactive results with the initial fourth-generation assay and nonreactive or indeterminate on the HIV-1/HIV-2 antibody differentiation immunoassay should be tested with an FDA-approved HIV-1 NAT to differentiate early HIV infection from a false-positive screening result [28] (Figure 2). HIV diagnostic tests: Serological diagnostic assays: Enzyme Immunoassays (EIA):Significant advances in the development of HIV immunoassays have been created since the discovery of HIV in 1983. Based on different design principles, HIV immunoassays are generally classified into generations. The earliest immunoassays (first-generation) are indirect EIAs that used coated viral lysate antigens derived from cell culture on a solid phase for antibody capture and an indirect format that detected antibody utilizing an enzyme-conjugated antihuman IgG [36]. Antibody can be detected within 8-10 weeks postinfection by first generation immunoassay. These assays have 99% sensitivity and 95-98% specificity for HIV infection. Second-generation immunoassays use synthetic peptide or recombinant protein antigens alone or in combination with viral lysates to bind HIV antibodies, and they use an indirect immunoassay format that employs conjugated antihuman IgG, which binds to IgG with high affinity, to detect IgG antibodies [37]. Utilizing recombinant anti gens in the second-generation assays improves sensitivity for HIV-1, HIV-1 group O, and HIV-2, allowing earlier detection of IgG antibodies. The sensitivity and specificity of second-generation assays have been reported to be ˃99.5% and ˃99%, respectively. First and second generation immunoassays can only detect IgG antibody to HIV. The window period was decreased to 4 to 6 weeks postinfection by second-generation assays. Third generation immunoassays also utilize synthetic peptide or recombinant antigens to bind HIV antibodies, but in an immunometric antigen sandwich format; HIV antibodies in the specimen bind to HIV antigens on the assay substrate and to antigens conjugated to indicator molecules. This allows detection of both IgM and IgG antibodies which leads to increase in sensitivity and specificity of the test. Lower sample dilutions and the ability to detect IgM antibodies (which are expressed before IgG antibodies) further decrease the window period to 2-3 weeks postinfection [38]. The reported sensitivity and specificity of third-generation assays is ˃99.5%. Combination or fourth-generation tests use synthetic peptide or recombinant protein antigens in the same antigen sandwich format as third-generation assays for the detection of IgM and IgG antibodies, and also monoclonal antibodies for the detection of p24 antigen [39]. Inclusion of p24 antigen capture allows the detection of HIV-1 infection before seroconversion and further decreases the window period. Most fourth-generation antigen/antibody immunoassays (termed combo assays) do not distinguish antibody reactivity from antigen reactivity [39]. Recent published data has shown that the fourth-generation assay was able to establish HIV infection in more than 80% of patients who tested NAAT positive but either nonreactive or indeterminate by other tests like Western blot, first to third generation immunoassays, and rapid tests [40-42]. Delaney et al. found that the fourth-generation immunoassay are able to detect HIV infection 1-3 weeks earlier than the first, second, and third generation immunoassay which cannot detect p24 antigen. The results of their study revealed that the median duration of the eclipse period was 11.5 days and 99% of specimens from HIV-infected patients could be reactive with Ag/Ab combination tests within 45 days of exposure. Moreover, for detection of antibodies by the IgG/IgM-sensitive and other plasma screening assays, 50 days or longer were required and after 3 month of exposure, infection could be detected by all tests. Several studies have reported sensitivities of 100% for fourth-generation immunoassay, whereas other surveys reported transient sensitivities range from 62-89% when assessed against HIV RNA assays. This decreased sensitivity can be attributed to the presence of a second diagnostic window. This situation is rare but it can happen. Second diagnostic window period lies between the p24 antigen detection and the anti-HIV antibody detection, and is associated with reduction in the p24 antigen and antigen/antibody complexes levels, as well as a delay in HIV-specific antibody development which totally may affect the sensitivity of fourth-generation immunoassays. So, it is possible that many acute HIV infections have been missed using fourth-generation assays. Despite negative results from a fourth-generation immunoassay in high-risk populations with suspected acute HIV infection, it is needed to repeat the test on new blood samples obtained several days later, as well as testing for HIV anti body alone, p24 antigen or use of an HIV RNA assay. In 2015, an improved version of immunoassay, BioPlex 2200 HIV Ag-Ab screening test system, received FDA approval in HIV screening which detects both HIV antibody and the HIV-1 p24 antigen by providing separate results for each analyte. This test also provides separate results for HIV-1 and HIV-2 antibodies, so there is no need for a HIV-1/2 differentiation assay for antibody reactive samples. It was reported that the sensitivity and specificity of BioPlex 2200 HIV Ag-Ab assay were 100 and 99.5%, respectively [43]. HIV Confirmatory Tests:Screening tests must be highly sensitive to produce few false-negative results, whereas confirmatory assays are characterized with high specificity to produce few false-positive results [44]. If the result of a screening test is repeatedly reactive, this has to be confirmed by (at least) one confirmatory assay. Western blot or indirect IFA traditionally have been employed as confirmatory assay due to their higher specificity. The probability that both ELISA and Western blot would give false-positive results is extremely low (

Cambridge Admissions Essay -- Cambridge Admissions Essay

Cambridge Admissions Essay As a child growing up in Communist China, I woke up every morning to the blasting of People's Central Broadcasting Station from a large radio on the dresser and fell asleep every evening in the surreptitious murmuring of Voices from America from a small radio by Grandpa's pillow. By fourth grade, I figured out that the two stations often reported the same events from opposite standpoints, using different words and tones, and thus projected contradictory interpretations onto the same events. Eager to share this revelation with my grandparents, I pointed out the differences between the two stations by singing their respective theme songs and by imitating the voices of their newscasters. To my disappointment, they were much more alarmed than amused. "Don't you talk nonsense in school," Grandma warned me. "You'll bring us trouble." With hindsight, I have realized that her reproach was no more than an attempt to protect what little freedom we did have. Back then, I knew only enough to keep my mouth shut, but I could not shut my mind off to questions that sprang up the more I listened, questions that shattered my faith in what I was taught. Like a small window that opened unto another world, the radio by Grandpa's pillow made me re-examine my own world in a new light. More than the accumulation of knowledge, learning, for me, means to test my own beliefs and prejudices against other points of view and to understand the reasons behind our differences. The classes I have taken at Harvard in the humanities and social sciences have shown me how to observe multiple layers of meaning in a given cultural situation, while campus journalism, internship with a documentary filmmaker, and summertime explorati... ..., philosophy and theater-as well as make a film composed of ten or twenty video "postcards," or an anthology of poetic fragments. Half will be detailed observations of Cambridge-thoughts on and video clips of spots I would frequent and of individuals I would see on a daily basis. The other half will be snapshots from travels to other parts of Europe-of places I may never see again and of strangers I will meet on the road. The most crucial criterion for inclusion in the anthology will be revelation-the moment captured has to be a window opening unto a different world, be it an idyllic countryside or warring battleground, an international city or a private home, a civilization that perished centuries ago or a community that has just come to be. This will allow me to explore the different possibilities of sharing what I see and experience with those not there with me.

concept of consciousness :: essays research papers

An individual is somewhere in space-time, and not somewhere else. Except for God, of course, who was invented to instantiate all contradictions in blessed harmony. He's everywhere and everywhen, though at the same time, as it were, not in time or space[3]. But the upshot of this is that every individual has a point of view, a perspective, and apprehends the world, so far as it can apprehend the world, from somewhere and not nowhere[4] (Nagel 1986). If taken in isolation, the feature of being somewhere in particular affects all kinds of individuals, not just humans. But only those individuals that can view something can presumably have a point of view. Thus Searle again: Subjectivity has the further consequence that all of my conscious forms of intentionality that give me information about the world independent of myself are always from a special point of view. The world itself has no point of view, but my access to the world through my conscious states is always perspectival. (ibid. 95).[5] In itself, however, that could be true of any other living thing. Nor is it a requirement to be alive: an artificial eye has a point of view. More generally, as shown in the excellent discussion of this subject in (Proust 1997), aspectuality can be seen as a consequence of mere differences of informational channels, and doesn't therefore require any level of consciousness. Perspective might itself be of two kinds. This can be seen by asking: Does a still camera have a genuine point of view? One reason to deny this is that for a still camera there is nothing that corresponds to the difference between locality in time, and locality in space. For a living individual, these pose slightly different problems. For there are different ways in which we might care about the effects of our actions in distant space, and in different times. Time is asymmetrical in this sense (among others): we care more, or quite differently, about what happens in the future than about what happened in the past. But although the things we care about may, of course, be unevenly distributed, space has no uniformly privileged direction. So temporal perspectivity appears seems to constitute a more serious species of subjectivity than the spatial kind. Now perspectivity is sometimes equated with subjectivity in general, as suggested in the last quotation from Searle above. Yet subjectivity is also associated with the self, and the temporal form of perspectivity actually causes problems for the view that my self is my subjectivity.

The Challenges of Fair Trade

Historically, coffee cultivation had brought a positive influence in developing countries to alleviate rural poverty. Paige (1997) and Williams (1994) also claimed that coffee cultivation had enabled households to develop their land holdings in sustainable, high return activity, and gainfully employ their family labor (as cited in Barham, Gitter, Lewis & Weber, 2011, p. 116). However, the global coffee market has fallen into crisis in recent years. A research conducted by Murray, Raynold and Taylor (2003), with a large decline in the coffee employment, many rural households have been forced to abandon traditional farming and adopt new livelihoods. Meanwhile, small scale but growing number of coffee farmers have participated in Fair Trade to try to survive such crisis. But, according to the research published recently, Fair Trade coffee may not only fail to bring the rural poor better life, it may impoverish them. This claim is supported by unbalanced price premium, limited Fair Trade coffee market and lack of Fair Trade knowledge by households. The higher sale price in Fair Trade coffee comparing to the conventional coffee is claimed to be the most direct benefit to individual rural farmers who participate in Fair Trade. As indicated by Barham et al. (2010), Fair Trade coffee growers receive an average US $344 in net cash income per hectare compared with US $192 for conventional growers (p. 120). Yet such premium price provided by the Fair Trade does not cover the cost to produce certified coffee for rural farmers. Weber (2011) states that if the coffee growers want to sell their products through Fair Trade, first they have to be certified (p. 109). Fair Trade Foundation requires coffee growers to pay high certification fees which the majority of Third World farmers are too poor to afford. In such cases, these growers are likely try to receive Fair Trade certification through cooperatives, but are required to share their net profit with cooperatives. For example, from the article What Price for Good Coffee? by Fieser and Padgett (2009) , Antonio, a coffee producer in Guatemala, receives 1. 55 dollars per pound of organic coffee sold through Fair Trade, approximately 10 percent more than the conventional market price. However, Antonio only receives less than 50 cents per pound after he pays Fair Trade cooperative fees, government taxes, farming expenses, and other costs (Fieser and Padgett, 2009, p. 98). This shows Fair Trade farmers often lose out on the premium price that can be fetched by certified coffee. Fair Trade is filled with contradictions. Even if the cooperatives and organizations are willing to lower the certification fees, the net cash income for growers participating in Fair Trade market is still not enough to cover the cost to produce certified coffee, by the fact that not all the high cost Fair Trade-organic certified coffee are sold at Fair Trade-organic certified coffee price. While Fair Trade coffee being organic is not a requisite for selling in Fair Trade market, most farmers that participate in cooperatives are expected to transit into organic coffee products and pass the organic certification (Weber, 2011, p. 110). However becoming organic certified requires a transition period. Weber (2011) claims it takes 3 years for growers to complete the transition into organic certification where they have to follow organic norms but unable to sell their coffee as organic (p. 111). This implies a significant delay between the time of the cost and when coffee starts yield a return. Such scenario above affects the net cash income received from Fair Trade households. Though some Fair Trade households do not transit themselves into organic certified coffee, the fact that most coffee grown by Fair Trade membership households is sold in the conventional markets is still true due to the lack of Fair Trade markets. Even though coffee is the second highest traded commodity, the market of Fair Trade coffee is relatively small with average 2. 5 % of the global coffee trade (Fieser and Padgett, 2009, p. 99). Barham et al. 2010) state that Fair Trade has limited the supply of coffee that labeled with certificated to keep the Fair Trade-organic coffee price up in the market. Therefore, even though the growers produce their coffee in a high cost Fair Trade-organic certification standards, they may have to sell their certified coffee to the markets that do not give the value of certification once Fair Trade refused their products (p. 122). Going through the effort to produce Fair Trade standards coffee, the farmers are not reaping the rewards they should have obtained. Also, with the lack of a consumer market but continually growing coffee producing households populations, Weber (2010) claims that it leads the cooperatives to increase their membership without expanding the market which results in lower premium for each household member (p. 113). The benefit to Fair Trade sales including price premiums, social premiums, long-term contracts, and low-interest credit are significantly reduced as less coffee is sold in Fair Trade markets (Murrary, 2003, p. 16). As a result, the limited and slow growth in the Fair Trade market has become one of the major concerns confronting Fair Trade production. Unconstrained market is the key to maximum returns; knowledge is the key ingredient to develop a more democratic institution. Yet households of coffee growers are facing the lack of clear knowledge for Fair Trade. Fair Trade is an indistinct concept to coffee growers comparing to coffee growing which appears in their daily farming livelihoods. Murrary et al. (2003) claim that coffee growers have not received regular and detailed training about information on Fair Trade, and have no contact with Fair Trade representatives but the cooperatives and the technical advisers (p. 6). Even more, majority of coffee growers identify Fair Trade with the cooperative. Such misinterpretation, leads some cooperatives to not tout the benefits coffee growers should gain as Fair Trade certification benefits (pp. 16 – 17). Since cooperatives and the technical advisers deal directly with the Fair Trade certification, buyers, and others; coffee growers simply have no control over their products com pare to other coffee investment patterns. For example, the Thrive's system mentioned by LaPorte (2013) in his article. Mr. Lander, an entrepreneur based in Atlanta, created the company named Thrive Farmers Coffee assisted coffee growers to increase their ownership and profit margins by splitting half of proceeds with farmers and by establishing relationships between farmers and local coffee co-ops. Mr. Lander also states that organizations like Thrive are trying to teach these growers the basic knowledge of risk and quality because now they see their products selling to their ultimate consumers (p. 106). If coffee growers can understand the way to prevent risk and way to improve coffee quality, these growers will most likely sell more coffee overall. In conclusion, Fair Trade is not the answer to solve poverty. The system offers limited price improvement to very few primary households, while neglecting the poorest of poor in the sector. With farmers lack of understanding of the structure and operation, Fair Trade can easily prevent the poor from liberating themselves, keep them in their land and restrain their future. And lastly, by raising Fair Trade coffee price for the consumer, it slows down the growth of global Fair Trade economy and limits the market from certain group. Overall, there are benefits to the small-scale farmers from Fair Trade movement, but the benefits are much insufficient compared with other investment patterns. It is nothing but a short-term diversion. If the Fair Trade is unable to put forward a plan for improving their current rate of returns, coffee growers are unlikely to lift themselves out of their poverty through Fair Trade. And, perhaps the only fair choice is to support free trade. References Abad-Vergara, Diane. (Director, Produce). (2009). Living with coffee [Documentary]. New Zealand. Barham, B. L., Callenes, M., Gitter, S., Lewis, J., ; Weber, J. (2011). Fair trade/organic coffee, rural livelihoods, and the â€Å"Agrarian Question†: Southern Mexican coffee families in transition. World Development, 39(1), 134-145. Fieser, E., ; Padgett, T. (2009). What price good coffee? Time International, 171(13) 90-91. La porte, N. (2013, March 16). Coffee’s economics, rewritten by farmers. New York Times. Retrieved 5/20/13 from  http://www.nytimes.com/2013/03/17/business/coffees-economics-rewritten-by-farmers.html Murray, D. L., Raynolds, L. T., ; Taylor, P.L. (2003). One cup at a time: poverty alleviation and fair trade coffee in Latin America. Fair Trade Research Group, Colorado State University. Weber, J. G. (2011). How much more do growers receive for Fair Trade-organic coffee? Food Policy, 36(5), 678-685

How Did the Constitution Guard Against Tyranny

How Did the Constitution Guard Against Tyranny? What do you think tyranny means? When we think of tyranny, we consider its harsh absolute power in the hands of one individual, like King George Ill. In James Madison's argument for his support of the Constitution he wrote that â€Å"The accumulation of all power†¦ in the same hands, whether of one, a few, or many is the very definition of tyranny. † In 1787, the framers came together in Philadelphia to write the Constitution to help guard against tyranny.The Constitution guarded gainst tyranny in several ways which were federalism, separation of power, checks and balances, and big states versus small states. The first guard against tyranny was federalism which means the federal principle of government. In the Federalist Paper #51 James Madison wrote that â€Å"In the compound republic of America, the power surrendered by the people is first divided between two distinct governments, and the portion allotted to each subdivid ed among distinct and separate departments. † (Doc. A). Madison's idea was known as Federalism, the division of ower between central and state governments.Federalism provides a double security to the people by the arise of the people's rights. Central and state governments have shared and separate powers. For instant, both governments set up courts and pass laws. Powers given to the Central Government were regulate trade, declaring war, setting up post offices, and making immigration laws. Powers given to the states were holding elections, setting up local governments, passing marriages and divorce laws, and establishing schools. Federalism protects against yranny because both governments were equal and gave people a say in the government.A second guard against tyranny was separation of power which means the government divided into three branches. They separated the government into the executive branch, legislative branch, and Judicial branch. In the Federalist Paper #47 James Madison said â€Å"The accumulation of all powers, legislative, executive, and judiciary, in the same hands, whether of one, a few, or many, and whether hereditary, self-appointed, or elective, may be Just pronounced the very definition of yranny†¦ † (Doc B). The idea Madison advocated with this quote was that through the separation of powers there tyranny shouldn't form.The Job of each branch is to protect the rights of the people. The separation of powers protects against tyranny because one branch cannot do something without the consultancy of another branch. This provided equal powers between the three branches. The third guard against tyranny was checks and balances which means a balance in power. As indicated in the chart, document C, the legislative branch or congress has check over he executive and Judicial branch it can override the vote of the executive branch and approve of presidential nominations. With the Judicial branch it could impeach judges and remove them from office.They could also do the same with the President and remove him or her from office. The executive branch could appoint Judges to the Supreme Court and can veto Congressional legislation. The Judicial branch can declare laws unconstitutional and declare presidential acts as unconstitutional. James Madison said that â€Å"†¦ (The three branches) should not be so far separated as to ave no constitutional control over each other,† meaning that without check and balances it would be one step closer to a tyranny, because one of the branches could gain all the control of the power (Doc C).In that the fght over how the states should be represented in congress began. The fourth and final step the delegates implied was the arguments between the small and big states and how they should be represented in congress. In the Constitutional Convention there was a big fuss over how the states should be represented, so that the big states votes or uggestions wouldn't overrid e the votes or suggestions of the smaller states. They came to the agreement known as the Great Compromise.In the compromise the agreed that under the House of Representatives the states would be represented by population (Doc. D). This made the larger states happier because they would have more representation over the smaller states. They also agreed to that the Senate of the United States shall be composed of two senators per state, making the smaller states happier because of the equal representation. With the compromise the states ould become united and this would help guard against tyranny.In the Constitutional Convention the delegates and Madison used arguments of federalism through the division of powers, checks and balances and the arguments between the larger and smaller states to guard against tyranny. Although checks and balances and the arguments between are important reason to prevent tyranny, the most important reason for the prevent of tyranny is the separation of pow ers, through the separation of powers the delegates insecurity of our rights. Therefore preventing one group gaining control of all powers. How Did The Constitution Guard Against Tyranny? Tyranny is a malicious enemy, it takes over and, will make you go against your will. The Articles Of Confederation was the first step the American Colonists took to get rid tyranny, but that dramatically failed. The Articles Of Confederation was missing many key parts such as a central government, there was no president, and the wasn’t even a court system. Also it didn’t justify a currency for the whole country.When you went to other states, they all had different currencies, so it was almost impossible to buy things, because people didn’t know how much one currency was worth compared to the other. Another problem the Articles Of Confederation didn’t cover was that there was no way for the central government to force states to pay their taxes. This was a problem because if states didn’t pay their taxes, the states would be a tyrant over the federal government. American Colonists decided that they needed a new constitution if they didn’t want the country to fall apart.The framers of the constitution protected us from the terrible evil of tyranny using four methods, which were, Federalism, dividing the government into three branches, a system of checks and balances, and preventing large states from creating a tyranny over the small states. Document A shows that the first step the framer took to protect us from tyranny was using a form of government called Federalism. Madison’s idea of division of power between central and state governments is known as federalism. (Doc A) From the chart in Document A, you can clearly see that this prevents any tyranny from happening.Powers that are needed to run a country are given to the federal government such as Declaring war, coining money, and conducting foreign relations. (Doc A) Also powers that are needed for a state are given, such as holding elections, and regulating in-state business. (Doc A) Powers that are needed by both states, and the federal law are shared. This prev ents any tyranny from happening because the states can’t take control of federal powers, and the federal government can’t take control of state powers. They can only take the power shared and the powers they own.The second step the framers took to protect us from tyranny was divide the central government into three branches. The section taken from the constitution it’s self shows the three branches of government. James Madison said, â€Å"the accumulation of all powers, legislative, executive, and judiciary, in the same hands, wether of one, a few, or many, and wether hereditary, self-appointed, or elected, may be justly pronounced the very definition of tyranny. (Doc B) The constitution clearly doesn’t put the powers of legislative, executive, and judiciary in one, or many hands.All the branches have split powers. The Legislative branch can only have the powers of congress. (Doc B) The Executive branch has powers vested within the president. (Doc B) Las tly, the Judicial branch has its powers vested in the highest court of the nation, the Supreme Court. As you can see the constitution prevents any branch to gain any more power from other branches. You may ask, â€Å"wasn’t Germany a democracy before Hitler took over? † Yes it was, but the next paragraph explains how the constitution prevented any other branch from taking over powers of another branch.The framers of the constitution created an ingenious way to prevent tyranny of one branch over other branches, with a system of checks and balances. James Madison said, â€Å"the constant aim is to divide and arrange the several offices in such a manner as that they may be a check on the other†. (Doc C) The diagram shows the branches have checks on each other. If the president tries to take the power of another branch, than the legislative branch can impeach the president. (Doc C) This is one of the checks of the legislative branch on the Executive branch.Each bran ch has a check of every other branch, so if one branch is doing something wrong, another branch can check the wronged branch, and fix the problem. This probably answers your question on how another branch can’t take control. One of the last things the framer of the constitution did to make sure no tyrant would arise, was to make sure the smaller states got a fair vote in congress. In the constitutional convention, two plans were proposed called the Virginia plan, and the New Jersey plan. The Virginia plan was favored large states, and was based of population.The New jersey plan favored small states, and gave each state an equal amount of votes. Eventually they came up of something called the great compromise, and they proposed that congress would be composed of the senate, and The House Of Representatives. The House Of Representatives is based of population, which provides fairness to large states. (Doc D) On the other hand, the Senate has two representatives from each state, which provides fairness to smaller states. (Doc D) Undoubtedly, this provides fairness among both large, and small states, ultimately taking a closer step to rid of tyranny.To sum it up, the framers of the constitution protected us from the terrible evil of tyranny using the four methods, Federalism, dividing the government into three branches, a system of checks and balances, and preventing large states from creating a tyranny over the small states in congress. James Madison said, â€Å"the accumulation of powers in the same hands, wether of one, a few, or many, is the very definition of tyranny† , and the constitution does a good job of preventing that. The framers succeeded in creating a well built constitution because all four methods have created security that no tyrant, or tyranny would arise.